Laboratory Diagnosis of Lassa Fever, Liberia
نویسندگان
چکیده
منابع مشابه
Laboratory Diagnosis of Lassa Fever, Liberia
ports on Lassa fever in southern and central parts of Nigeria. That healthcare workers are still at as high a risk of contracting and dying from the disease as they were 20 years ago (8) is alarming. A key to solving this problem would be the establishment of diagnostic facilities that can provide rapid molecular testing at referral centers in the disease-endemic zones. This testing would facil...
متن کاملPathogenesis of Lassa Fever
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for hospitalized patients varying between 5-10%. Currently, there are no approved vaccines against Lassa fever for use in humans. Here, we review the publishe...
متن کاملEarly diagnosis of Lassa fever by reverse transcription-PCR.
We developed a method based on a coupled reverse transcription-PCR (RT-PCR) for the detection of Lassa virus using primers specific for regions of the S RNA segment which are well conserved between isolates from Sierra Leone, Liberia, and Nigeria. The specificity of the assay was confirmed by Southern blotting with a chemiluminescent probe. The assay was able to detect 1 to 10 copies of a plasm...
متن کاملLaboratory diagnosis of glandular fever.
A common feature of the numerous published studies on glandular fever is the wide variation encountered in the clinical and pathological manifestations of the disease (Davidsohn, 1952). This has permitted the clinician to label a wide variety of illnesses as glandular fever even in the presence of persistently negative laboratory findings. It is, therefore, far from clear whether the diagnosis ...
متن کاملLassa Fever, Nigeria, 2005–2008
To the Editor: Lassa fever affects ≈100,000 persons per year in West Af-rica (1). The disease is caused by Las-sa virus, an arenavirus, and is associated with bleeding and organ failure. The case-fatality rate in hospitalized patients is 10%–20%. The reservoir of the virus is multimammate mice (Mastomys natalensis). Investigations in the 1970s and 1980s pointed to the existence of 3 disease-end...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2010
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1606.100040